Psoriasis and systemic inflammation: underdiagnosed enthesopathy

Psoriasis: A Disease of Systemic Inflammation with Comorbidities

The majority of the current data about psoriasis is about immune system elements and role of inflammation in the pathogenesis. The development of psoriasis is associated with genetic predisposition which has a basis of T cell activation secondary to dermal inflammation with abnormal keratinocyte proliferation. Tumor necrosis factor alpha (TNF-α), interferon gama (IFN-γ), and interleukin (IL)-8 ...

Psoriasis, a Systemic Disease?

It has long been recognized the epidemiological association of psoriasis, especially the most severe forms, with several diseases that share a common pathogenic substrate involving TNF-α and different target organs (arthritis and Crohn disease, for example), as well as an increased risk of coronary heart disease and occlusive cardiovascular disease. In the patient with severe psoriasis there is...

[Psoriasis, a systemic disease?].

It has long been recognized the epidemiological association of psoriasis, especially the most severe forms, with several diseases that share a common pathogenic substrate involving TNF-alpha and different target organs (arthritis and Crohn's disease, for example), as well as an increased risk of coronary heart disease and occlusive cardiovascular disease. In the patient with severe psoriasis th...

Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences

Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, comprising inflammation, hyperproliferation, and angioneogenesis, intrigues num...

Comparison between ultrasound and magnetic resonance imaging of achilles tendon enthesopathy in patients with psoriasis.